Identifying the right sites and implementing processes to streamline site activation, start-up, and operations is a complex and challenging endeavor. The convergence of evolving regulations, patient- and site-centric practices, DEI initiatives, real-world data, advanced analytics, and digital and decentralized models are reshaping traditional feasibility approaches. SCOPE’s 15th Annual Feasibility & Study Start-Up stream will address these challenges by exploring innovative strategies and methodologies. The Data-Informed Feasibility and Investigator Selection conference will focus on analytics-driven global site selection, incorporating patient- and site-centric approaches to planning and execution, and developing creative solutions into minimize site burden. Meanwhile, the Tech and Collaboration to Streamline Start-Up and Reduce Operational Burden conference will provide insights into strategies that support sites through operational challenges, enhance DEI objectives, and leverage technologies and processes to optimize study deployment.