The growing demand for sites with access to targeted patient populations, coupled with increasingly challenging operational burdens on sites due to proliferation of new technologies and complex protocols, requires new ways of working with sites to modernize clinical trials for the future. The Inaugural Site Engagement & Enablement conference offers new approaches for reducing site burden and frameworks for establishing long-term partnerships from both the sponsor and site perspectives. The Collaborative Strategies to Improve Trial Execution conference highlights new strategies for establishing and nurturing long-term relationships with investigational sites and institutions, and solutions to optimize trial execution.  The Tech and Collaboration to Streamline Start-Up and Reduce Operational Burden conference explores new technologies and processes to reduce site burden and improve site-facing training, while providing site perspectives on complexities and costs of executing trials and what they need from sponsors.