Clinical trial success increasingly depends on thoughtful protocol design that prioritizes input from patients and sites while leveraging the power of data, technology, and innovative trial models. Engaging patients and sites early in the design process leads to more practical, efficient, and participant-friendly protocols—ultimately improving recruitment, retention, and trial outcomes. SCOPE’s 4th Annual Trial Design & Protocol Development stream offers a focused look at strategies and frameworks to modernize trial design by integrating stakeholder feedback, digital tools, and new and emerging designs such as decentralized, hybrid, and pragmatic trials. Attendees will gain actionable insights into designing trials that are not only operationally effective but also aligned with the real-world needs and experiences of patients and sites.