Identifying the right sites and implementing processes to streamline site activation, start-up, and operations is a complex and challenging endeavor. The convergence of evolving regulations, patient- and site-centric practices, DEI initiatives, real-world data, advanced analytics, and digital and decentralized models are reshaping traditional feasibility approaches. SCOPE’s 16th Annual Feasibility & Site Selection stream highlights how organizations are using real-world data and predictive analytics to inform global site selection, applying inclusive frameworks to reach underrepresented populations, and adopting new tools to align site capabilities with protocol requirements. Attendees will gain practical insights into modernizing feasibility processes and making smarter, data-informed decisions that set trials up for success from the start.