The 16th Annual Real World Evidence stream at the SCOPE Summit will explore the evolving landscape of RWD integration into clinical research. Building on previous discussions, this stream will focus on how diverse data sources are increasingly shaping study design and regulatory decisions. As the boundary between traditional clinical trials and real-world data research continues to shift, innovative data technologies, advanced analytics, and strategic collaborations are critical to unlocking actionable insights. The role of AI in analyzing complex RWD sets the stage for more efficient, patient-centric research and accelerated product development. This program aims to foster collaboration among healthcare providers, biopharma, regulators, and data partners, driving forward the strategic use of RWD in clinical and observational studies.