Life sciences organizations have invested heavily in generating real-world evidence (RWE), yet many struggle to translate those insights into sustained changes in clinical practice, patient behavior, and organizational decision-making. This presentation introduces the concept of execution architecture and explores how implementation science, knowledge translation, and human-centered design can bridge the gap between evidence generation and real-world impact.

As AI capabilities rapidly advance, pharmaceutical organizations are rethinking how evidence is generated, verified, and communicated. This session compares AI adoption journeys of Clinical Development and Real-World Evidence teams, highlighting how priorities have evolved from task automation to workflow transformation. Speakers will share practical lessons on strategy, governance, and implementation, and discuss the future role of AI in enabling faster, more scalable and effective evidence generation across the research enterprise.

Pragmatic trials increasingly use real-world data (RWD) and privacy-preserving linkage to extend follow-up beyond protocol windows, reduce participant burden, and capture outcomes from routine care. However, dataset selection often relies on simple token overlap (i.e., whether a participant appears in a dataset), which may obscure whether required variables are available with sufficient completeness. A cloud-first approach enables secure, early feasibility assessment to guide fit-for-purpose RWD selection without moving underlying data.

Electronic health record (EHR) to electronic data capture (EDC) interoperability has been proven through pilots, established standards, and advancing technology, yet adoption remains fragmented across the clinical research ecosystem. If the technology exists, what barriers remain for EHR-to-EDC to scale globally? This session explores a shared vision for a future in which research-relevant EHR data can be exchanged and reused across sponsors, sites, studies, and technology platforms without bespoke implementations or proprietary dependencies.

Drawing on TransCelerate's EHR Connectivity initiative, presenters will share insights from ecosystem assessments and stakeholder engagement, highlighting the progress achieved and the technical, operational, governance, and validation barriers that remain. Attendees will explore what it will take to move from isolated successes to broad adoption and will be challenged to join a holistic industry effort to build the roadmap, partnerships, and reusable assets needed to make scalable EHR-to-EDC interoperability a reality